A .30 cal suppressor can typically handle calibers up to .30 caliber, such as .308 Winchester, .300 Blackout, 7.62x39mm, 300 WinMag, and 6.5 Creedmoor. It can also be used with smaller calibers like 5.56 NATO. Some silencers will have barrel length restrictions, fire rate recommendations, or specific caliber ratings.